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Feedback inhibition of dihydrodipicolinate synthase enzymes by L-lysine
1Max-Planck Institut für Biochemie, Martinsried, Germany.
Biological Chemistry
|March 1, 1997
Abstract:
Dihydrodipicolinate synthase (DHDPS) is the first enzyme unique to the lysine biosynthetic pathway and is feedback regulated by L-lysine in plants and some bacteria. The allosteric binding site has been localized by X-ray crystallography and is in agreement with reported mutations of plant DHDPS enzymes, which confer insensitivity to feedback inhibition. Three possible elements of the mechanism of lysine inhibition are discussed.