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Effect of coronary angioplasty on precordial QT dispersion
A Yunus1, A M Gillis, M Traboulsi
1The Division of Cardiology, Foothills Hospital & The University of Calgary, Alberta, Canada.
Insights
QT interval dispersion, a measure of ventricular repolarization, decreases after successful coronary artery revascularization. Increased dispersion may indicate recurrent ischemia due to restenosis following angioplasty.
Area of Science:
- Cardiology
- Electrophysiology
- Ischemic Heart Disease
Background:
- QT interval dispersion reflects ventricular repolarization inhomogeneity.
- Ischemia can cause regional conduction and repolarization abnormalities.
Purpose of the Study:
- To investigate QT interval dispersion changes in patients with coronary artery disease undergoing percutaneous transluminal coronary angioplasty (PTCA).
- To determine if successful revascularization reduces QT interval dispersion.
- To assess QT interval dispersion as a marker for restenosis and recurrent ischemia.
Main Methods:
- Evaluated 37 patients with 1-vessel coronary artery disease without prior myocardial infarction undergoing PTCA.
- Performed electrocardiograms 24 hours before, 24 hours after, and late (>2 months) after PTCA.
- Calculated precordial QT interval dispersion from maximum and minimum corrected QT intervals.
Main Results:
- Mean QT interval dispersion significantly decreased post-PTCA (60±9 ms pre-PTCA to 23±14 ms post-PTCA, p<0.001).
- Shortest precordial QT interval increased post-PTCA (367±40 ms to 391±39 ms, p<0.02).
- Increased dispersion was observed with restenosis (56±15 ms) and decreased after repeat PTCA (22±13 ms).
Conclusions:
- Successful coronary artery revascularization reduces QT interval dispersion.
- QT interval dispersion may serve as a marker for recurrent ischemia due to restenosis after PTCA.
Abstract:
Dispersion of the QT interval is a measure of inhomogeneity of ventricular repolarization. Because ischemia is associated with regional abnormalities of conduction and repolarization, we hypothesized that the surface electrocardiographic interval dispersion would increase in patients with symptomatic coronary artery disease in the absence of myocardial infarction and that successful revascularization would reduce QT interval dispersion. Thirty-seven consecutive patients with ischemia due to 1-vessel coronary artery disease without prior myocardial infarction who underwent percutaneous transluminal coronary angioplasty (PTCA) were evaluated. Standard 12-lead electrocardiograms were performed 24 hours before, 24 hours after, and late (>2 months) after PTCA. Precordial QT interval dispersions were determined from differences in the maximum and minimum corrected QT intervals. Mean QT interval dispersion before PTCA was 60 +/- 9 ms, immediately after PTCA 23 +/- 14 ms (p <0.001), and late after PTCA 29 +/- 18 ms (p <0.001 vs before PTCA). The shortest precordial QT interval increased immediately after PTCA (367 +/- 40 vs 391 +/- 39 ms; p <0.02) and then remained stable late after PTCA (376 +/- 36 ms, p = NS vs immediately after PTCA). Symptomatic recurrent ischemia in 8 patients with documented restenosis increased QT interval dispersion (56 +/- 15 ms [p <0.01] vs 25 +/- 14 ms immediately after PTCA), which decreased again after successful repeat PTCA (22 +/- 13 ms [p <0.01] vs before the second PTCA). QT interval dispersion decreases after successful coronary artery revascularization and increases with restenosis. Therefore, QT interval dispersion may be a marker of recurrent ischemia due to restenosis after PTCA.