Related Experiment Video
Updated: Jul 21, 2026
Determination of Continuity Index Values in Atrial Fibrillation Ablation with Proactive Esophageal Cooling
Published on: April 19, 2024
Evaluation of an open-loop, computer-based infusion system designed to achieve a series of constant, targeted plasma
J D Coyle1, C A Carnes, S F Schaal
1Division of Pharmacy Practice and Administration, College of Pharmacy, Ohio State University, Columbus 43210, USA.
Study Objective:
To evaluate the performance of a computer-based procainamide infusion system in patients undergoing electrophysiologic testing.
Design:
Prospective case series.
Setting:
Electrophysiology laboratory in a university hospital.
Patients:
Thirty-four patients with inducible sustained ventricular tachycardia.
Interventions:
Intravenous infusion of procainamide to achieve and maintain targeted plasma concentrations.
Measurements And Main Results:
System performance was assessed by comparing targeted and observed plasma concentrations. The population median absolute performance error (size of typical miss) was 12.6% (95% CI 11.2-14.1%). The population median performance error (system bias) was not significantly different from zero. A small but statistically significant improvement in performance over time was observed (population absolute performance error divergence -0.125%/min). Population wobble (overall system stability) was 7.6% (95% CI 6.8-8.3%). Population-based estimates of central compartment volume and volume of distribution at steady state were significantly higher and lower, respectively, than estimates used by the infusion system.
Conclusion:
The computer-based infusion system is capable of achieving and maintaining a series of targeted procainamide concentrations in patients undergoing electrophysiologic testing.
Related Concept Videos
01:30Pulse rhythm
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac muscle...
01:09One-Compartment Model: IV Infusion
The one-compartment model for IV infusion uses mathematical equations to describe the rate of change in drug quantity in the body. At steady-state or infusion equilibrium, the drug input...
01:15Two-Compartment Open Model: IV Infusion
The model illustrates the decrease in plasma drug concentration from the central compartment with a specific equation. It shows that under steady-state conditions, the drug's input rate...
01:15Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations