Are repeated desmopressin treatment attempts successful?

The efficacy of repeated treatment attempts using desmopressin (Minirin, DDAVP), either alone, alternately or in combination with an alarm device, were evaluated in 96 patients with primary nocturnal enuresis who were slow, delayed or non-responders to therapy. At follow-up, 52% of the patients were cured and off therapy, an additional 26% had achieved dryness when using desmopressin regularly or on special occasions, and 22% were still wetting. It can be concluded that desmopressin therapy can be successfully commenced at the age of 5 years. Repeated treatment attempts can lead to achievement of dryness at an earlier stage. However, they probably do not influence the final outcome.