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Echinococcus multilocularis: mouse strain difference in hydatid development

K Nakaya1, M Nakao, A Ito

  • 1Animal Laboratory for Medical Research, Asahikawa Medical College, Asahikawa 078, Japan.

Journal of Helminthology
|March 1, 1997
PubMed
Summary

Mouse strain genetics significantly influence Echinococcus multilocularis development. Non-H-2 genes, not the H-2 complex, appear to regulate key differences in hydatid vesicle and protoscolex formation.

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Area of Science:

  • Immunology
  • Parasitology
  • Genetics

Background:

  • Echinococcus multilocularis infection causes cystic echinococcosis.
  • Host genetic factors are known to influence parasitic disease progression.

Purpose of the Study:

  • To investigate the impact of different inbred mouse strains on Echinococcus multilocularis larval development.
  • To identify potential genetic loci regulating hydatid development.

Main Methods:

  • Female mice from nine inbred strains and one H-2 congenic strain were infected with Echinococcus multilocularis.
  • Liver tissues were examined histologically 9 and 13 weeks post-infection to assess parasite development.

Main Results:

  • Significant variations in hydatid development were observed across mouse strains.

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  • Multivesiculation was prominent in C57BL/10, DBA/1, C57BL/6, and BALB/c strains.
  • Protoscolex development varied, with DBA/2, AKR, DBA/1, and CBA showing well-developed protoscoleces. The H-2 congenic B10.D2 strain showed inhibited protoscolex development, similar to C57BL/10.

    • Conclusions:

    • Host genetic background plays a crucial role in Echinococcus multilocularis hydatid development.
    • The observed differences in hydatid morphology suggest regulation by non-H-2 genes.