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Partial Klüver-Bucy Syndrome following probably herpes simplex encephalitis
Journal of Neurology
|September 1, 1979
Summary
Herpes simplex encephalitis (HSE) can lead to partial Klüver-Bucy syndrome, characterized by oral, emotional, and sexual changes. This neurological sequela appears weeks to months after the acute infection, indicating temporal lobe involvement.
Area of Science:
- Neurology
- Infectious Diseases
- Neuroscience
Background:
- Herpes simplex encephalitis (HSE) is a severe viral infection of the brain.
- Klüüver-Bucy syndrome (KBS) is a behavioral disorder resulting from damage to the temporal lobes.
- The association between HSE and KBS is not widely recognized.
Observation:
- An autopsy case of probable HSE presented with partial Klüver-Bucy syndrome.
- Symptoms included hyperorality, emotional lability, and possible hypersexuality.
- These neurological manifestations appeared 1-7 months post-HSE onset.
Findings:
- Review of literature revealed several cases of partial or complete KBS in HSE survivors.
- KBS emerged 2 weeks to 1 month after the acute phase of HSE.
- The syndrome suggests bilateral temporal lobe and limbic system involvement.
Implications:
- Klüüver-Bucy syndrome should be considered in prolonged or surviving cases of HSE.
- Recognizing KBS in HSE aids in understanding the extent of brain damage.
- This association highlights the neurotropic potential of herpes simplex virus.