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Related Experiment Videos

Effect of retinoic acid on prostatic development

S R Aboseif1, R Dahiya, P Narayan

  • 1Department of Urology, University of California, School of Medicine, San Francisco 94143-0738, USA.

The Prostate
|May 15, 1997
PubMed
Summary

Retinoids like 13-cis-retinoic acid and all-trans-retinoic acid inhibit rat prostate ductal branching morphogenesis. This effect is reversible and mediated by retinoic acid receptors (RARs).

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Area of Science:

  • Developmental Biology
  • Molecular Endocrinology

Background:

  • Prostatic ductal branching morphogenesis is crucial for prostate development.
  • Retinoids are known regulators of cell growth and differentiation.

Purpose of the Study:

  • To investigate the effects of specific retinoids on prostatic ductal branching in vitro.
  • To explore the underlying molecular mechanisms involving retinoic acid receptors.

Main Methods:

  • Anterior rat prostates were cultured ex vivo with testosterone and various retinoids (13-cis-RA, at-RA, 4-HPR).
  • Morphologic complexity was quantified to assess ductal branching.
  • Reverse transcription polymerase chain reaction (RT-PCR) was used to analyze nuclear receptor gene expression.

Main Results:

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  • 13-cis-retinoic acid and all-trans-retinoic acid dose-dependently inhibited prostate ductal growth and branching.
  • The inhibitory effect of 13-cis-retinoic acid was reversible upon retinoid removal.
  • 4-hydroxyphenyl-retinamide (4-HPR) did not affect ductal morphogenesis.

Conclusions:

  • Retinoids significantly impact prostate ductal branching morphogenesis.
  • Retinoic acid receptors, specifically RAR-beta and RAR-gamma, are present in the developing prostate and likely mediate these effects.