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Unidentified antioxidant defences of human plasma in immobilized patients: a possible relation to basic metabolic
R Aejmelaeus1, T M Ketelä, T Pirttilä
1Laboratory of Neurobiology, Medical School, University of Tampere, Finland.
Free Radical Research
|April 1, 1997
Abstract:
Plasma total peroxyl radical scavenging capacity was studied in terminal patients who were chronically immobilized because of an acute (stroke) or chronic neurodegenerative disease (Alzheimer's disease). A luminometric assay was used to measure total antioxidant capacity (TRAP). The immobilized patients showed significant decrease in TRAP primarily because of a decrease in the concentration of unknown antioxidants. Our results suggest that human plasma may contain unknown antioxidants, the regulation of which could be related to the basic metabolic rate.