Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Evolving concepts of chemical sensitivity

¹National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA.

Environmental Health Perspectives

|March 1, 1997

Summary

Individual differences in chemical sensitivity vary widely, potentially spanning orders of magnitude. Conditioning adverse physiological effects may explain some aspects of this complex phenomenon.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Episodic ozone exposure in adult and senescent Brown Norway rats: acute and delayed effect on heart rate, core temperature and motor activity.

Inhalation toxicology·2014

Same author

Ozone induces glucose intolerance and systemic metabolic effects in young and aged Brown Norway rats.

Toxicology and applied pharmacology·2013

Same author

Susceptibility of adult and senescent Brown Norway rats to repeated ozone exposure: an assessment of behavior, serum biochemistry and cardiopulmonary function.

Inhalation toxicology·2013

Same author

Acute administration of dopaminergic drugs has differential effects on locomotion in larval zebrafish.

Pharmacology, biochemistry, and behavior·2013

Same author

Toluene effects on the motor activity of adolescent, young-adult, middle-age and senescent male Brown Norway rats.

Neurotoxicology·2011

Same author

Assessing locomotor activity in larval zebrafish: Influence of extrinsic and intrinsic variables.

Neurotoxicology and teratology·2011

Area of Science:

Environmental Health
Toxicology
Neuroscience

Background:

Chemical sensitivity is a poorly understood phenomenon.
Individual susceptibility to chemicals varies significantly within populations.
Understanding these differences is crucial for public health and safety.

Framework:

Investigating individual differences in susceptibility to chemicals.
Exploring the role of conditioning in the etiology of chemical sensitivity.
Utilizing laboratory animal models to study physiological responses.

Implementation:

Assessing the range of sensitivity to manufactured chemicals in populations.
Conducting studies on laboratory animals to determine sensitivity ranges.
Developing rigorous laboratory models for investigating chemical sensitivity.

Implications:

Provides insights into the range of chemical sensitivity within a population.
Suggests conditioning plays a role in the development of chemical sensitivity.
Offers a framework for future research into the causes of chemical sensitivity.

Related Experiment Videos