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Calcium and chemotropic turning of nerve growth cones
J Q Zheng1, M M Poo, J A Connor
1Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
Perspectives on Developmental Neurobiology
|January 1, 1996
Abstract:
Cultured Xenopus spinal neurons exhibit chemotropic turning toward the source of neurotransmitters acetylcholine and glutamate. Here we review the experimental evidence that transmitter-induced turning of the growth cone is mediated by an influx of Ca2+, that a gradient of intracellular Ca2+ within the growth cone is responsible for the directional growth cone response, and that asymmetric filopodia formation precedes and is essential for the turning response.