Related Experiment Videos
Bone marrow transplantation in children. Imaging assessment of complications
1Department of Radiology, University of Chicago Children's Hospital, Illinois, USA.
Insights
Awareness of potential complications following bone marrow transplantation (BMT) in children is crucial. Imaging plays a key role in diagnosing these complications across various body systems.
Area of Science:
- Pediatric Medicine
- Radiology
- Hematology
Background:
- Bone marrow transplantation (BMT) is increasingly used for pediatric malignant and nonmalignant diseases.
- Recognizing post-BMT complications in children is essential for timely management.
Purpose of the Study:
- To review the imaging appearance of central nervous system, paranasal sinus, lung, abdominal, and pelvic complications in pediatric BMT recipients.
- To highlight the role of various imaging modalities in diagnosing these complications.
Main Methods:
- Review of imaging findings in children post-BMT.
- Correlation of imaging findings with clinical data.
Main Results:
- Central nervous system (CNS) pathology is best defined with contrast-enhanced CT and MR imaging.
- Paranasal sinus and lung diseases require plain films supplemented by CT.
- Abdominal and pelvic complications are effectively identified using ultrasound and CT.
Conclusions:
- Multimodality imaging is critical for the comprehensive evaluation of pediatric BMT complications.
- Radiologists must be familiar with the diverse imaging manifestations of post-BMT complications.
Abstract:
As the use of BMT increases for the treatment of a variety of malignant and nonmalignant diseases in children, awareness of the complications that can occur in these children is important. The imaging appearance of the complications that may occur in the central nervous system, paranasal sinus, lungs, abdomen, and pelvis in children following BMT have been reviewed. CT and MR imaging examination with the use of contrast material as indicated is important for defining pathology in the brain. Plain films should be supplemented with CT examination as needed to identify and characterize disease in the paranasal sinuses and lungs. Finally, the use of ultrasound and CT is crucial for defining complications that may occur in the abdomen and pelvis.