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Myelodysplastic syndrome presenting with clonal rearrangement isolated to chromosomal region 1q
M J Mogul1, K Brady, A R Brothman
1Division of Pediatric Hematology, Oncology, and Bone Marrow Transplant, Emory University School of Medicine, Atlanta, Georgia, 30322, USA.
Cancer Genetics and Cytogenetics
|June 1, 1997
Abstract:
Myelodysplastic syndrome (MDS) is a malignant hematologic disorder that may present with clinical features consistent with the diagnosis of severe aplastic anemia (SAA). Distinguishing the two disorders may depend on the presence of a clonal chromosomal abnormality. In the following, we report a case of MDS associated with what we believe to be a previously unreported clonal abnormality of chromosome 1q, a finding that enabled us to distinguish between MDS and SAA.