Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reversible brain MRI changes in acyclovir neurotoxicity

M E Blohm1, W Nürnberger, A Aulich

  • 1Department of Paediatric Haematology and Oncology, Heinrich Heine University Medical Centre, Dusseldorf, Germany.

Bone Marrow Transplantation
|May 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction to: No difference in survival after HLA mismatched versus HLA matched allogeneic stem cell transplantation in Ewing sarcoma patients with advanced disease.

Bone marrow transplantation·2021
Same author

No difference in survival after HLA mismatched versus HLA matched allogeneic stem cell transplantation in Ewing sarcoma patients with advanced disease.

Bone marrow transplantation·2021
Same author

A De Novo Dominant Negative Mutation in DNM1L Causes Sudden Onset Status Epilepticus with Subsequent Epileptic Encephalopathy.

Neuropediatrics·2019
Same author

A structural view of synthetic cofactor integration into [FeFe]-hydrogenases.

Chemical science·2018
Same author

Development of curative therapies for Ewing sarcomas by interdisciplinary cooperative groups in Europe.

Klinische Padiatrie·2015
Same author

Targeting the EWS-FLI1 transcription factor in Ewing sarcoma.

Cancer chemotherapy and pharmacology·2015
Same journal

A multimodal sexual health intervention among hematopoietic stem cell transplant recipients: mediating effects on quality of life and mood.

Bone marrow transplantation·2026
Same journal

Excellent clinical and patient-reported outcomes following matched sibling donor BMT for sickle cell disease.

Bone marrow transplantation·2026
Same journal

The risk of anxiety and depression in Swedish potential stem cell donors-need for increased psychological evaluation and support?

Bone marrow transplantation·2026
Same journal

False-positive HIV-1 RNA detection following obecabtagene autoleucel.

Bone marrow transplantation·2026
Same journal

T-cell replete haploidentical transplantation compared to mismatched unrelated allogeneic transplantation with post-transplantation cyclophosphamide in patients with secondary acute myeloid leukemia in first complete remission: A study from the ALWP/EBMT.

Bone marrow transplantation·2026
Same journal

The role of allogeneic stem cell transplantation in peripheral T-cell lymphoma.

Bone marrow transplantation·2026
See all related articles

Acyclovir toxicity can cause reversible brain MRI changes, including seizures, in pediatric patients. Neuroimaging findings resolved after discontinuing the antiviral medication.

Area of Science:

  • Neurology
  • Radiology
  • Pharmacology

Background:

  • Acyclovir is a commonly used antiviral medication.
  • Neurotoxicity is a potential adverse effect of acyclovir.
  • Previous neuroimaging studies in acyclovir toxicity have yielded limited or inconclusive results.

Observation:

  • A 12-year-old girl developed seizures after receiving prophylactic intravenous acyclovir post-stem cell transplantation.
  • Cerebral Magnetic Resonance Imaging (MRI) revealed multiple areas of gadolinium enhancement and blood-brain barrier disruption.
  • Infectious etiologies for the neurological symptoms were ruled out.

Findings:

  • The observed brain MRI changes were likely attributable to acyclovir toxicity.
  • The patient's clinical symptoms and MRI abnormalities resolved completely within 9 days of acyclovir cessation.

Related Experiment Videos

  • This case highlights the potential for acyclovir to induce significant, yet reversible, central nervous system pathology.

    • Implications:

    • This case provides crucial evidence of characteristic neuroimaging findings in acyclovir toxicity.
    • It underscores the importance of considering acyclovir-induced neurotoxicity in patients presenting with neurological symptoms.
    • The findings suggest that prompt discontinuation of acyclovir can lead to complete recovery from associated neurological deficits and imaging abnormalities.