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Leukemia inhibitory factor and ciliary neurotrophic factor in sensory neuron development
A R Horton1, A M Davies, A Buj-Bello
1School of Biological and Medical Sciences, University of St. Andrews, Fife, Scotland.
Perspectives on Developmental Neurobiology
|January 1, 1996
Summary
Leukemia inhibitory factor (LIF) and related proteins support sensory neuron development and survival. These neurotrophic factors influence neuron differentiation, survival, and neurotransmitter expression throughout development.
Area of Science:
- Neuroscience
- Developmental Biology
- Cell Biology
Background:
- Leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) are key neurotrophic factors.
- These factors are implicated in the development and maintenance of the nervous system.
Purpose of the Study:
- To investigate the role of LIF, CNTF, and related proteins in sensory neuron development.
- To understand how these factors influence neuronal differentiation, survival, and neurotransmitter expression.
Main Methods:
- Review of existing evidence on LIF, CNTF, and related proteins in sensory neuron development.
- Analysis of studies examining the effects of these factors on neuronal differentiation and survival.
Main Results:
- LIF promotes the differentiation of sensory neurons from neural crest progenitor cells.
- LIF, CNTF, oncostatin M, and interleukin-6 support the survival of cultured sensory neurons.
- Neuronal responses to these factors vary, with some responding early (e.g., nodose ganglion) and others late (e.g., trigeminal ganglion).
- LIF may also influence neurotransmitter and neuropeptide expression in sensory neurons.
Conclusions:
- LIF and related factors play multifaceted roles in sensory neuron development.
- These factors influence differentiation, survival, and neurochemical properties at different developmental stages.
- The differential timing of responses suggests distinct roles for these factors in various sensory neuron populations.