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Related Experiment Videos

MR multispectral analysis of multiple sclerosis lesions

J R Mitchell1, C Jones, S J Karlik

  • 1Department of Diagnostic Radiology and Nuclear Medicine, University of Western Ontario, London, Canada.

Journal of Magnetic Resonance Imaging : JMRI
|May 1, 1997
PubMed
Summary

New magnetic resonance imaging (MRI) techniques can detect changes in multiple sclerosis (MS) lesion composition, even when lesion volume remains stable. This offers improved sensitivity for assessing MS disease activity in clinical trials.

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In Vivo 7T MR Quantitative Susceptibility Mapping Reveals Opposite Susceptibility Contrast between Cortical and White Matter Lesions in Multiple Sclerosis.

AJNR. American journal of neuroradiology·2016

Area of Science:

  • Neuroimaging
  • Radiology
  • Neurology

Background:

  • Assessing multiple sclerosis (MS) disease activity in clinical trials typically relies on lesion volume quantification from serial magnetic resonance imaging (MRI) examinations.
  • Pathologic changes within MS lesions may occur without a corresponding change in lesion volume, potentially limiting the sensitivity of current assessment methods.
  • Improved methods are needed to detect subtle disease activity and pathologic changes in MS.

Purpose of the Study:

  • To introduce and evaluate a novel technique for analyzing the intensity composition of MS lesions in standard spin-echo MRI examinations.
  • To assess whether this new technique can detect disease activity by analyzing lesion composition, independent of volume changes.
  • To compare lesion intensity distributions over time to identify fluctuations indicative of disease activity.

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Main Methods:

  • A new technique was developed based on multispectral "feature space" intensity distributions of lesions and normal tissues in standard spin-echo MRI.
  • The technique reduces multidimensional intensity distributions to one dimension, preserving information about lesion composition (related to proton density, T2, and interecho delay).
  • Eight MS lesions in three patients were analyzed, with examinations calibrated using cerebrospinal fluid (CSF) as an internal reference.

Main Results:

  • Lesion intensity distributions showed a characteristic peak at low intensity, corresponding to normal-appearing white matter (WM).
  • Increases in high-intensity peaks within lesion distributions were often accompanied by reductions in the WM peak.
  • Serial analysis revealed significant fluctuations in lesion intensity distributions, even when lesion volume remained constant.

Conclusions:

  • The developed technique provides valuable information about the intensity composition of MS lesions.
  • Analysis of lesion intensity composition offers a more sensitive method for detecting MS disease activity compared to lesion volume alone.
  • This technique has the potential to enhance the assessment of disease progression and treatment efficacy in multiple sclerosis clinical trials.