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Plasma levels of cyclic GMP, immune parameters and depressive status during interferon therapy. A prospective study
A Kagaya1, Y Uchitomi, E Takezaki
1Department of Psychiatry and Neurosciences, Hiroshima Univeristy School of Medicine, Japan.
Abstract:
In this report, we investigated the relationship between depressive symptoms and plasma interferon (IFN)-alpha-like immunoreactivity, cyclic GMP (cGMP) and soluble interleukin-2 receptor (sIL-2R) levels during IFN therapy. An altered mood state was observed in 5 of 26 patients. IFN-alpha-like immunoreactivity in the depressed group tended to be elevated. cGMP levels of depressed patients were significantly greater than those of control subjects before and 6 weeks after IFN therapy. However, sIL-2R levels were not different between the two groups. These results suggest that a number of patients suffered from depression during IFN therapy and that patients had greater concentrations of cGMP levels.