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Remnant-like particle cholesterol may indicate atherogenic risk in patients on chronic hemodialysis
1Second Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
Insights
Remnant-like particle cholesterol (RLP-C) is elevated in hemodialysis patients compared to controls. Higher RLP-C levels correlate with increased atherogenic risk factors, suggesting its potential as an indicator in this population.
Area of Science:
- Cardiovascular Research
- Nephrology
- Clinical Biochemistry
Background:
- Atherosclerosis is a growing concern in hemodialysis (HD) patients.
- The role of remnant-like particle cholesterol (RLP-C) in atherosclerosis is recognized, but not well-studied in HD populations.
Purpose of the Study:
- To investigate the relationship between RLP-C levels and various lipid parameters, oxidative stress markers, and apolipoproteins in HD patients.
- To assess the correlation of RLP-C with atherogenic indices in HD patients.
Main Methods:
- Serum RLP-C levels were measured in HD patients and normal controls.
- Lipid profiles (TC, TG, LDL-C, HDL-C), malondialdehyde (MDA), apolipoproteins (ApoA-I, ApoB), and lipoprotein fractions (VLDL, IDL, LDL, HDL) were analyzed.
- Correlations between RLP-C and clinical/biochemical parameters, including atherogenic indices, were examined.
Main Results:
- HD patients exhibited significantly higher RLP-C levels than controls (8.2 vs. 2.7 mg/dl).
- RLP-C positively correlated with total cholesterol, triglycerides, LDL-C, MDA, ApoB, VLDL(%), and IDL(%), and negatively with HDL-C.
- RLP-C showed positive correlations with atherogenic indices [(TC-HDL-C)/HDL-C and (VLDL+LDL)/HDL] and a negative correlation with ApoA-I/ApoB.
Conclusions:
- RLP-C is significantly elevated in hemodialysis patients.
- RLP-C levels are closely associated with atherogenic lipid profiles and oxidative stress markers.
- RLP-C may serve as a valuable indicator of atherogenic risk in patients undergoing hemodialysis.
Abstract:
Recently, involvement of remnant-like particle cholesterol (RLP-C) in atherosclerosis was reported, but this parameter has not been adequately investigated in hemodialysis (HD) patients. The present study investigated the relationship between the RLP-C level and total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), lipid peroxides (malone dialdehyde, MDA), apolipoprotein (Apo) A-I, and ApoB. In addition, the fractions of very low density lipoprotein (VLDL), intermediate density lipoprotein (IDL), LDL, and HDL in serum lipoproteins were determined by disk polyacrylamide gel electrophoresis. The relationship between the RLP-C level and three atherogenic indices was also studied. The RLP-C level in HD patients (8.2 +/- 6.7 mg/dl) was significantly higher than that in normal controls (2.7 +/- 1.3 mg/dl). The RLP-C level showed a significant positive correlation with the levels of TC, TG, LDL-C, MDA, ApoB, VLDL(%), and IDL(%), as well as a negative correlation with HDL(%). However, there was no correlation with age or the duration of HD. RLP-C also showed significant positive correlations with the (TC -HDL-C)/HDL-C ratio and the (VLDL + LDL)/HDL ratio, as well as a negative correlation with the ApoA-I/ApoB ratio. These results suggest that RLP-C may be a potential indicator of atherogenic risk in HD patients.