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Chronic infection of Balb/c mice with murine herpesvirus 72 is associated with neoplasm development
J Mistríkóva1, J Rajcáni, M Mrmusová
1Department of Microbiology and Virology, Faculty of Natural Sciences, Comenius University, Bratislava, Slovak Republic.
Acta Virologica
|November 1, 1996
Abstract:
One hundred Balb/c mice were infected with murine herpesvirus strain 72 (MHV-72) and observed for 2.5 years for neoplasm development and virus presence in tumour as well as non-tumour tissues. Out of 13 neoplasm-bearing mice the virus was recovered from solid tumours (one lymphoma, two non-differentiated lymphoblastomas and two fibrosarcomas) of five mice and from the spleen of one mouse with lymphatic leukemia. The virus persisted frequently also in various organs of the neoplasm-bearing mice.