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Related Experiment Video

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Bioluminescence Imaging of Heme Oxygenase-1 Upregulation in the Gua Sha Procedure

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Ocular quinine toxicity treated with hyperbaric oxygen

R S Wolff¹, D Wirtschafter, C Adkinson

¹Department of Ophthalmology, University of Minnesota, Minneapolis, USA.

Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc

|June 1, 1997

Summary

Hyperbaric oxygen therapy (HBOT) shows promise for treating quinine-induced vision loss. Two patients regained full vision after HBOT for ocular quinine toxicity.

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Area of Science:

Ophthalmology
Toxicology
Hyperbaric Medicine

Background:

Ocular quinine toxicity can cause severe, permanent vision loss.
Current treatments like gastric lavage and activated charcoal have limited efficacy.
Hyperbaric oxygen (HBO2) therapy aims to enhance retinal oxygen delivery.

Observation:

Two patients presented with bilateral no light perception vision and nonreactive pupils after ingesting large doses of quinine.
Initial treatment included oral activated charcoal.
Both patients received hyperbaric oxygen therapy (HBO2) at 2.4 atm abs with 100% O2 for 90 minutes within 17 hours of ingestion.

Findings:

Remarkable visual recovery to 20/20 acuity in both eyes occurred in less than 24 hours post-treatment.
Follow-up visual field testing revealed residual constriction and paracentral scotomas.

Implications:

Hyperbaric oxygen therapy (HBO2) may be a valuable addition or alternative treatment for ocular quinine toxicity.
This approach offers a potentially safer therapeutic option for patients with quinine-induced visual impairment.
Further research is warranted to establish optimal protocols and long-term outcomes for HBO2 in managing quinine toxicity.