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Related Experiment Videos

Ocular quinine toxicity treated with hyperbaric oxygen

R S Wolff1, D Wirtschafter, C Adkinson

  • 1Department of Ophthalmology, University of Minnesota, Minneapolis, USA.

Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc
|June 1, 1997
PubMed
Summary

Hyperbaric oxygen therapy (HBOT) shows promise for treating quinine-induced vision loss. Two patients regained full vision after HBOT for ocular quinine toxicity.

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Area of Science:

  • Ophthalmology
  • Toxicology
  • Hyperbaric Medicine

Background:

  • Ocular quinine toxicity can cause severe, permanent vision loss.
  • Current treatments like gastric lavage and activated charcoal have limited efficacy.
  • Hyperbaric oxygen (HBO2) therapy aims to enhance retinal oxygen delivery.

Observation:

  • Two patients presented with bilateral no light perception vision and nonreactive pupils after ingesting large doses of quinine.
  • Initial treatment included oral activated charcoal.
  • Both patients received hyperbaric oxygen therapy (HBO2) at 2.4 atm abs with 100% O2 for 90 minutes within 17 hours of ingestion.

Findings:

  • Remarkable visual recovery to 20/20 acuity in both eyes occurred in less than 24 hours post-treatment.

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  • Follow-up visual field testing revealed residual constriction and paracentral scotomas.

    • Implications:

    • Hyperbaric oxygen therapy (HBO2) may be a valuable addition or alternative treatment for ocular quinine toxicity.
    • This approach offers a potentially safer therapeutic option for patients with quinine-induced visual impairment.
    • Further research is warranted to establish optimal protocols and long-term outcomes for HBO2 in managing quinine toxicity.