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Design and Synthesis of a Reconfigurable DNA Accordion Rack
Published on: August 15, 2018
Segmented structure of separate and transposable DNA and RNA elements as suggested by their size distributions
1Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel. bptrifol@weizmann.weizmann.ac.il
Abstract:
A collection of about 1000 different eukaryotic and prokaryotic DNA mobile and separate elements is compiled from literature-transposons, plasmids, extrachromosomal circular DNA, insertion sequences, as well as viral genomes and separate genome segments. Only small elements are collected, upto 2000 base pairs. Analysis of the sequence length distributions of the elements reveals that certain sizes are clearly preferred, namely those which correspond to multiples of about 345 bp in eukaryotes and multiples of about 210 bp in prokaryotes. This provides additional evidence in support of the theory (1) that segmented structure is characteristic of not only protein-coding sequences (2) but rather of genomes in general. In particular, it confirms the prediction (1) that mobile and separate elements would also be segmented.
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