[Asymptotic behavior of calculated concentration time curves]
Related Experiment Video
Updated: Nov 1, 2026

Chemical Triphosphorylation of Oligonucleotides
Published on: June 2, 2022
1Abteilung Medizinische Informatik, Universität Göttingen.
Abstract:
The measured concentration time curve of an injected substance is often used as a basis for calculating the distribution volume. For the first time, the present paper describes a generally applicable formula for calculating the asymptote of a concentration time curve in medical applications. With a knowledge of this formula, previously unexplained phenomena (varying results obtained from two different methods of calculating the distribution volume) can now be understood. At the same time, errors of methodology (choice of injection and measuring sites) can be avoided.
Related Concept Videos
Concentration and Rate Law
For example, in a generic reaction aA + bB ⟶ products, where a and b are stoichiometric coefficients, the rate law can be written as:
Calculating Equilibrium Concentrations
A more...
The Integrated Rate Law: The Dependence of Concentration on Time
Pharmacodynamic Models: Linear Concentration–Effect Model
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations
Time Course of Drug Effect

