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Brucella abortus siderophore 2,3-dihydroxybenzoic acid protects brucellae from killing by macrophages
B A Leonard1, I Lopez-Goni, C L Baldwin
1Department of Microbiology, Ohio State University, Columbus 43210, USA.
Veterinary Research
|January 1, 1997
Abstract:
Addition of 2,3-dihydroxybenzoic acid, a siderophore produced by Brucella abortus, to macrophage cultures prevented intracellular killing of brucellae during the first 12 h after infection and increased the number of intracellular brucellae recovered at 48 h after infection. The protective effect could be demonstrated with inflammatory macrophages, interferon-gamma-activated macrophages and with macrophages supplemented with iron, shown elsewhere to facilitate killing of B abortus.