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[Postmenopausal osteoporosis: therapeutic approaches]
P Affinito1, S Palomba, C Sorrentino
1Cattedra di Ginecologia e Ostetricia, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli, Federico II, Napoli.
Minerva Ginecologica
|March 1, 1997
Summary
Post-menopausal osteoporosis treatments vary, with no single protocol. Estrogens, progestogens, bisphosphonates, calcitonin, ipriflavone, fluorides, calcium, calcitriol, and synthetic steroids offer preventive and therapeutic options for bone loss.
Area of Science:
- Endocrinology and Bone Metabolism
- Pharmacology of Osteoporosis Treatments
Context:
- Post-menopausal osteoporosis lacks a definitive intervention protocol.
- Various pharmacological agents are available for prevention and therapy.
Purpose:
- To review and summarize current preventive and therapeutic measures for post-menopausal osteoporosis.
- To outline the mechanisms of action and applications of different treatment options.
Summary:
- Estrogens and progestogens prevent bone loss by acting on mineral components and collagen.
- Bisphosphonates inhibit bone resorption; calcitonin increases bone mass and reduces fractures.
- Ipriflavone, fluorides, calcium, calcitriol, and synthetic steroids (ORG: OD 14) also play roles in managing bone turnover and preventing bone loss.
Impact:
- Provides a comprehensive overview of osteoporosis management strategies.
- Highlights the diverse pharmacological approaches for preserving bone health in post-menopausal women.
- Informs clinical decision-making regarding the selection of appropriate osteoporosis therapies.