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Updated: Aug 8, 2026

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
Published on: April 1, 2022
Abstract:
Chronic pancreatitis is frequently observed in men drinking approximately 2 g-kg-1 day-1 during a mean of 17 years. The diet of these patients is abnormally rich in fat and protein. Giving alcohol and a similar diet to dogs and rats, it has been possible to reproduce chronic alcoholic pancreatitis. In men, dogs and rats, the first lesion seems to be the precipitation of the normal proteins of pancreatic juice into the ducts. Experimentally, chronic alcohol consumption is responsible for the section of a pancreatic juice which has an abnormally high concentration of proteins. This functional modification is partly hormonal but mostly due to cholinergic nerves.
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Acute Pancreatitis I: Introduction
Chronic Pancreatitis I: Introduction
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