Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Coeliac disease

C C Booth

    Nutrition and Metabolism
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Coeliac disease involves gluten-induced intestinal damage, primarily in the jejunum, with compensatory ileal hyperabsorption. This adaptation can lead to asymptomatic cases, suggesting many undiagnosed coeliac disease patients exist.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Correlation of Radiological and Histological Findings in Idiopathic Steatorrhoea.

    British medical journal·2010
    Same author

    Medical radicals in the age of the Enlightenment.

    Journal of medical biography·2002
    Same author

    Changing concepts of health and disease during the 20th century.

    Journal of the Royal College of Physicians of London·2000
    Same author

    Choosing a dermatological hero for the millennium. Robert Willan (1757-1812).

    Clinical and experimental dermatology·2000
    Same author

    Robert Willan MD FRS (1757-1812): dermatologist of the millennium.

    Journal of the Royal Society of Medicine·1999
    Same author

    Smoking and the Royal College of Physicians.

    Clio medica (Amsterdam, Netherlands)·1998
    Same journal

    Dietary fats and platelet function in French and Scottish farmers.

    Nutrition and metabolism·1980
    Same journal

    Plasma lipoproteins in maturity onset diabetes.

    Nutrition and metabolism·1980
    Same journal

    Dietary effects on blood pressure.

    Nutrition and metabolism·1980
    Same journal

    Recent international changes in coronary heart disease mortality.

    Nutrition and metabolism·1980
    Same journal

    High and low high-density lipoproteins: clinical implications.

    Nutrition and metabolism·1980
    Same journal

    Intestinal lipoprotein formation.

    Nutrition and metabolism·1980
    See all related articles

    Area of Science:

    • Gastroenterology
    • Immunology
    • Genetics

    Background:

    • Coeliac disease is an intestinal mucosal abnormality triggered by gluten ingestion.
    • The primary lesion affects the proximal small intestine, sparing the ileum or causing less severe involvement.

    Purpose of the Study:

    • To explain the mechanism of jejunal malabsorption and ileal hyperabsorption in coeliac disease.
    • To investigate why some individuals with coeliac disease remain asymptomatic despite intestinal lesions.

    Main Methods:

    • The study describes the characteristic absorptive abnormalities in coeliac disease.
    • It discusses adaptive changes in the ileum compensating for jejunal malabsorption.

    Main Results:

    • Jejunal malabsorption and ileal hyperabsorption are characteristic absorptive abnormalities.

    Related Experiment Videos

  • Adaptive ileal changes can compensate for jejunal lesions, potentially leading to asymptomatic disease.
  • A genetically determined basic lesion, likely involving impaired antigen clearance and immune complex formation, is proposed.

    • Conclusions:

    • Asymptomatic coeliac disease may be more prevalent than clinically diagnosed cases due to ileal compensation.
    • The underlying pathology is likely a genetically determined failure to clear gut antigens, leading to immune complex formation.