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[Intestinal lavage solution for orthograde intestinal irrigation]
C Gruy-Kapral1, W Base, L Kramer
1Konventspital der Barmherzigen Brüder Linz.
Wiener Klinische Wochenschrift
|March 14, 1997
Summary
Electrolyte solutions with non-absorbable substances effectively cleanse the colon for procedures. Mannitol-based solutions are better tolerated, but polyethylene glycol solutions with flavoring may improve palatability.
Area of Science:
- Gastroenterology
- Clinical Nutrition
- Pharmacology
Background:
- Colon cleansing with electrolyte solutions is crucial for endoscopic procedures.
- Non-absorbable substances prevent fluid and electrolyte imbalances.
- Systematic studies on different lavage solutions are limited.
Purpose of the Study:
- To evaluate the influence of gut lavage solutions with varying electrolyte composition and non-absorbable substances on homeostasis and tolerance.
- To compare the efficacy and patient acceptance of different colon lavage solutions.
Main Methods:
- A randomized, blind study in healthy volunteers using nasogastric tube infusion of 6 liters of three different solutions.
- A double-blind clinical study in 26 patients undergoing colonoscopy, who drank 4 liters of solutions.
- Measurements included body weight, serum electrolytes, and subjective tolerance.
Main Results:
- No significant changes in body weight or serum electrolytes were observed in healthy volunteers.
- Patients drank mannitol and low-sodium solutions significantly faster than polyethylene glycol and high-sodium solutions.
- All solutions provided adequate colon cleansing with comparable side effects, though palatability varied.
Conclusions:
- Gut lavage solutions with balanced electrolytes and non-absorbable substances (mannitol or polyethylene glycol) are equivalent for colon cleansing.
- Mannitol solutions with low sodium are better tolerated but pose risks during endoscopy.
- Flavoring may improve the palatability of polyethylene glycol-based solutions.