[Hypoxia and vascular-platelet hemostasis in patients with acute coronary insufficiency]

This study was aimed at investigation of a relationship between the parameters of hypoxia and platelet function and the antiaggregation activity of the vascular wall in patients with acute coronary failure. Seventy-four patients aged 31 to 78 with unstable angina were examined. Prior to the treatment capillary and venous blood gases, activities of superoxide dismutase, catalase, levels of malonic dialdehyde and diene conjugates, and red cell peroxide resistance were measured. Platelet aggregation was studied before and after occlusion test. According to multifactorial statistical analysis, the type of gas exchange and lipid peroxidation processes has a strong impact on platelet function and antiaggregation activity of the vascular wall in patients with unstable angina. Hypoxia in these patients is associated with both pathogenic and compensatory changes in the vascular-platelet component of the homeostasis system, which should be borne in mind when carrying out antihypoxic therapy.