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Candida norvegensis: a fluconazole-resistant species
P Sandven1, K Nilsen, A Digranes
1Department of Bacteriology, National Institute of Public Health, Oslo, Norway.
Antimicrobial Agents and Chemotherapy
|June 1, 1997
Summary
Candida norvegensis is an uncommon cause of human infections. All identified isolates, even from before 1940, showed resistance to fluconazole, suggesting this is an inherent trait.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Candida norvegensis is a rare cause of human infections.
- Previous studies have documented its presence in clinical settings.
Purpose of the Study:
- To investigate the prevalence and antifungal susceptibility of Candida norvegensis in human infections.
- To determine if fluconazole resistance in Candida norvegensis is a recent phenomenon or an inherent characteristic.
Main Methods:
- Retrospective analysis of clinical isolates of Candida norvegensis.
- Antifungal susceptibility testing, specifically for fluconazole.
Main Results:
- Eight isolates of Candida norvegensis were identified in Norway between 1990 and 1996.
- Four of these isolates were deemed to be of probable pathogenic significance.
- All tested isolates, including those from before 1940, exhibited resistance to fluconazole.
Conclusions:
- Candida norvegensis infections, though unusual, can be clinically significant.
- Fluconazole resistance appears to be an inherent characteristic of Candida norvegensis, not acquired over time.