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Related Experiment Videos

Intrathecal methotrexate overdose

A C Lee1, K W Wong, K W Fong

  • 1Department of Paediatrics, Tuen Mun Hospital, New Territories, Hong Kong.

Acta Paediatrica (Oslo, Norway : 1992)
|April 1, 1997
PubMed
Summary
This summary is machine-generated.

Two children received a tenfold overdose of intrathecal methotrexate, leading to seizures. Prompt treatment with folinic acid and dexamethasone resulted in complete recovery, highlighting medication safety needs.

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Area of Science:

  • Pediatric Oncology
  • Neuro-oncology
  • Clinical Pharmacy

Background:

  • Intrathecal chemotherapy is crucial for treating central nervous system involvement in pediatric cancers.
  • Methotrexate is a common chemotherapeutic agent used intrathecally.
  • Accidental medication overdoses can have severe consequences, especially in pediatric patients.