Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The house that Jak/Stat built

D E Levy1

  • 1Department of Pathology, NYU School of Medicine, NY 10016, USA. levyd01@mcrcr.med.nyu.edu

Cytokine & Growth Factor Reviews
|March 1, 1997
PubMed
Summary
This summary is machine-generated.

Remarkable progress in cytokine signal transduction has been achieved, focusing on the Janus kinase/signal transducer and activator of transcription (Jak/Stat) pathway. Research addressed specificity through biochemical, molecular, and genetic studies of these critical signaling pathways.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differential effect by chronic disease risk: A secondary analysis of the ChooseWell 365 randomized controlled trial.

Preventive medicine reports·2024
Same author

Seasonal variability in environmental tobacco smoke exposure in public housing developments.

Indoor air·2014
Same author

STAT1-regulated lung MDSC-like cells produce IL-10 and efferocytose apoptotic neutrophils with relevance in resolution of bacterial pneumonia.

Mucosal immunology·2012
Same author

Distinct inflammatory signals have physiologically divergent effects on epigenetic regulation of Foxp3 expression and Treg function.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2011
Same author

Restricted tissue tropism and acquired resistance to Sindbis viral vector expression in the absence of innate and adaptive immunity.

Gene therapy·2007
Same author

A phase II trial of perifosine in locally advanced, unresectable, or metastatic pancreatic adenocarcinoma.

American journal of clinical oncology·2007
Same journal

Tissue-resident immune cells in tumors: Cytokine-mediated regulation, functional plasticity, and therapeutic opportunities.

Cytokine & growth factor reviews·2026
Same journal

Shared and context-specific mechanisms of T cell exhaustion in chronic viral infections and cancer: Transcriptional, metabolic, epigenetic, and therapeutic perspectives.

Cytokine & growth factor reviews·2026
Same journal

Temporal dynamics of type I interferon signaling in checkpoint inhibitor response and resistance.

Cytokine & growth factor reviews·2026
Same journal

The role of osteoprotegerin in colorectal cancer: Molecular interactions, mechanistic insights, and therapeutic implications.

Cytokine & growth factor reviews·2026
Same journal

Designing next-generation interleukin immunotherapy: A cytokine-guided framework for precision cancer therapy.

Cytokine & growth factor reviews·2026
Same journal

Fibroblast growth factor homologous factors in neural signaling: Molecular mechanisms and disease-relevant dysregulation.

Cytokine & growth factor reviews·2026
See all related articles

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Cytokine signaling is crucial for immune responses and cellular communication.
  • The Janus kinase/signal transducer and activator of transcription (Jak/Stat) pathway is a key mediator of cytokine action.
  • Understanding cytokine signal transduction complexity is vital for deciphering cellular processes.

Framework:

  • The workshop focused on the specificity of cytokine signaling.
  • Investigated signal transduction pathways using biochemical, molecular, and genetic approaches.
  • Addressed the complexities of cytokine-mediated cellular responses.

Implementation:

  • Experimental results from various studies were presented and discussed.
  • Biochemical assays were used to analyze protein interactions and modifications.

Related Experiment Videos

  • Molecular and genetic techniques were employed to elucidate pathway components and functions.

    • Implications:

    • Advances in understanding cytokine signaling can lead to new therapeutic strategies.
    • Elucidating the Jak/Stat pathway's role in specificity offers insights into immune regulation.
    • This research provides a foundation for further exploration of signal transduction in health and disease.