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Related Experiment Videos

Enterotropic mouse hepatitis virus

F R Homberger1

  • 1Institute of Laboratory Animal Science, University of Zurich, Switzerland. frhom@ltk.unizh.ch

Laboratory Animals
|April 1, 1997
PubMed
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Mouse hepatitis virus (MHV), a common laboratory mouse pathogen, causes subclinical infections that impact research, especially in immunology. MHV strains vary in virulence and tropism, requiring careful colony management and detection.

Area of Science:

  • Veterinary Virology
  • Immunology
  • Laboratory Animal Science

Background:

  • Mouse hepatitis virus (MHV) is a prevalent coronavirus in laboratory mice.
  • MHV infections, often subclinical, significantly impact immunological research outcomes.
  • Understanding MHV is crucial for maintaining the integrity of biomedical research.

Purpose of the Study:

  • To provide a comprehensive overview of Mouse Hepatitis Virus (MHV) in laboratory settings.
  • To highlight the impact of MHV on research, particularly in immunology.
  • To discuss the characteristics, strains, and control of MHV infections.

Main Methods:

  • Review of existing literature on MHV pathogenesis, molecular biology, and epidemiology.
  • Analysis of MHV strain variations in virulence and tissue tropism.

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  • Discussion of diagnostic and control strategies for MHV in mouse colonies.

    • Main Results:

    • MHV possesses a positive-sense RNA genome and comprises four to five structural proteins.
    • Strains are classified as polytropic or enterotropic based on tissue tropism.
    • Infections are generally acute and self-limiting in adults but severe in neonates, though passive immunity offers protection.

    Conclusions:

    • MHV is a significant confounding factor in immunological studies due to its prevalence and impact on biological responses.
    • Effective management relies on serological screening, culling, and rederivation techniques.
    • Continued vigilance and understanding of MHV are essential for reliable laboratory animal models.