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Haemostatic changes in patients with deep vein thrombosis
A Trifiletti1, R Scamardi, M A Pizzoleo
1Chair of Angiology, Messina University, Italy.
Panminerva Medica
|March 1, 1997
Summary
Deep vein thrombosis (DVT) patients exhibit elevated levels of D-dimer (DD), beta-thromboglobulin (beta-TG), and plasminogen activator-inhibitor (PAI-1). These findings indicate a common hypercoagulable state in individuals with DVT.
Area of Science:
- Hematology
- Vascular Medicine
- Clinical Biochemistry
Background:
- Deep vein thrombosis (DVT) is a significant vascular condition.
- Understanding the hemostatic balance in DVT is crucial for diagnosis and treatment.
- Biomarkers of coagulation and fibrinolysis play a key role in assessing thrombotic states.
Purpose of the Study:
- To investigate plasma levels of key hemostatic markers in patients with newly-diagnosed DVT.
- To compare these levels against those in healthy controls.
- To determine if specific markers indicate a hypercoagulable state in DVT.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used for plasma analysis.
- Measurements included thrombomodulin (TM), beta-thromboglobulin (beta-TG), D-dimer (DD), tissue-type plasminogen-activator (t-PA), plasminogen activator-inhibitor (PAI-1), and functional protein S (PS).
- The study included 16 untreated DVT patients and 10 healthy volunteers.
Main Results:
- No significant differences were found in plasma TM, t-PA, and PS levels between DVT patients and controls.
- Significantly higher plasma levels of DD, beta-TG, and PAI-1 were observed in DVT patients compared to controls.
- These elevated markers suggest an activation of the coagulation and fibrinolysis systems.
Conclusions:
- Patients with deep vein thrombosis commonly present with a hypercoagulable state.
- Elevated DD, beta-TG, and PAI-1 are indicative of this prothrombotic condition.
- These markers may serve as potential indicators for DVT-associated hypercoagulability.