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Related Experiment Videos

RNA editing and hypermutation by adenosine deamination

B L Bass1

  • 1Department of Biochemistry, University of Utah, Salt Lake City 84112, USA. bass@msscc.med.utah.edu

Trends in Biochemical Sciences
|May 1, 1997
PubMed
Summary

Double-stranded RNA adenosine deaminase (dsRAD) research has revealed surprising findings. Discoveries include its membership in a larger deaminase family and in vivo RNA targets.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • Double-stranded RNA adenosine deaminase (dsRAD) was identified a decade ago.
  • Initial research focused on enzyme purification and cDNA identification.

Purpose of the Study:

  • To review progress in dsRAD research over the past ten years.
  • To highlight surprising discoveries beyond predictable advancements.

Main Methods:

  • Literature review of dsRAD research.
  • Analysis of published findings on enzyme family classification and in vivo RNA targets.

Main Results:

  • dsRAD belongs to a larger family of adenosine deaminases.
  • Specific RNA molecules have been identified as potential in vivo targets for these enzymes.

Conclusions:

  • dsRAD research has yielded unexpected insights into its biological role.
  • The enzyme family and its RNA targets represent significant areas for future investigation.

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