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Pharmacological characterization of synaptic transmission through mGluRs in rat cerebellar slices
A M Batchelor1, T Knöpfel, F Gasparini
1The Cruciform Project, University College London, U.K.
Neuropharmacology
|March 1, 1997
Abstract:
The mGluR-mediated EPSP at parallel fibre-Purkinje cell synapses in the cerebellum was blocked concentration-dependently and reversibly by antagonists acting selectively on group-I mGluRs but not by an inhibitor of group-III receptors. The results provide pharmacological evidence that the receptor type responsible for the mGluR-EPSP is mGluR1.