Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aortic intimal changes in aging swine

A Kamio, W Y Huang, B H Cho

    Paroi Arterielle
    |June 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Development of machine learning models for the surveillance of colon surgical site infections.

    The Journal of hospital infection·2023
    Same author

    Estimation of Right-Lobe Graft Weight From Computed Tomographic Volumetry for Living Donor Liver Transplantation.

    Transplantation proceedings·2017
    Same author

    Interface between intramembranous and endochondral ossification in human foetuses.

    Folia morphologica·2014
    Same author

    Clinical outcome of intentional replantation with preoperative orthodontic extrusion: a retrospective study.

    International endodontic journal·2014
    Same author

    An immunohistochemical study of matrix proteins in the craniofacial cartilage in midterm human fetuses.

    European journal of histochemistry : EJH·2014
    Same author

    Mechanism of arginine transport in Chlorella.

    Planta·2013

    Aging swine aortas show smooth muscle and monocyte-like cells in intimal lesions. These cells, along with accumulated lipids, contribute to aortic plaque development in aged swine.

    Area of Science:

    • Cardiovascular Biology
    • Cellular Biology
    • Aging Research

    Background:

    • Aortic intimal lesions are a hallmark of cardiovascular aging.
    • Understanding the cellular composition and lipid accumulation in these lesions is crucial for aging research.

    Purpose of the Study:

    • To characterize the cellular constituents of aortic intimal lesions in aging swine.
    • To investigate the lipid content and extracellular matrix accumulation in aging swine aortas.

    Main Methods:

    • Histological and ultrastructural examination of aortic intimal lesions.
    • Biochemical analysis of lipid content (cholesterol, triglycerides, phospholipids) in aortic intima-media.

    Main Results:

    • Aortic intimal lesions contained smooth muscle cells, monocyte-like cells, and unclassifiable cells.

    Related Experiment Videos

  • Monocyte-like cells, resembling circulating monocytes, were found in the innermost intimal layer and possessed heterophagic vacuoles.
  • Lipid content (cholesterol, triglycerides, phospholipids) was significantly higher in older swine aortas compared to younger ones.
  • Cultured aortic cells accumulated extracellular components similar to those found in aged swine aortic plaques.

    • Conclusions:

    • Smooth muscle cells are the predominant cell type in aging swine aortic intimal lesions.
    • Monocyte-like cells appear to pre-exist in lesions and contribute to their development.
    • Increased lipid content and extracellular matrix accumulation are characteristic of aging swine aortas, potentially contributing to atherosclerosis.