Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

In experimental diabetes the decrease in the eye of lens carnitine levels is an early important and selective event

P Pessotto1, R Liberati, O Petrella

  • 1Research, Sigma-Tau S.p.A., Pomezia, Rome, Italy.

Experimental Eye Research
|February 1, 1997
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

New onset of guttate psoriasis, Hallopeau's continuous acrodermatitis, and psoriatic arthritis after COVID-19 vaccine.

Scandinavian journal of rheumatology·2024
Same author

Hippo signaling instructs ectopic but not normal organ growth.

Science (New York, N.Y.)·2022
Same author

New onset of remitting seronegative symmetrical synovitis with pitting oedema and palmoplantar psoriasis flare-up after Sars-Cov-2 vaccination.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same author

Hexavalent vaccines in preterm infants: an update by Italian Society of Pediatric Allergy and Immunology jointly with the Italian Society of Neonatology.

Italian journal of pediatrics·2019
Same author

Stochastic cell renewal process and lengthening of cell cycle.

Physical biology·2019
Same author

Subclinical atherosclerosis and endothelial dysfunction in patients with polymyalgia rheumatica: a pilot study.

Scandinavian journal of rheumatology·2019

Carnitine depletion in the eye lens is an early indicator of diabetes in rats and rabbits. This significant carnitine loss in the lens, unlike in serum, may contribute to cataract formation.

Area of Science:

  • Biochemistry
  • Ophthalmology
  • Diabetology

Background:

  • Carnitine is found in eye tissues, particularly the lens.
  • Diabetes is associated with metabolic changes affecting various tissues.

Purpose of the Study:

  • To investigate carnitine levels in eye tissues during diabetes.
  • To explore the relationship between lens carnitine loss and cataract development.

Main Methods:

  • Induction of diabetes in rats using streptozotocin and in rabbits using alloxan.
  • Quantification of carnitine levels in lens and serum at various time points.
  • Comparison of carnitine levels between diabetic and control subjects.

Main Results:

  • Significant carnitine reduction in rat lenses (63% at 8 days) and rabbit lenses (85% at 4 months) post-diabetes induction.

Related Experiment Videos

  • Lens carnitine loss occurred independently of consistent hyperglycemia.
  • Serum carnitine levels showed less pronounced changes compared to lens levels.

    • Conclusions:

    • Lens carnitine depletion is an early event in experimental diabetes.
    • The loss of carnitine in the lens may be linked to cataract formation.
    • Acetylcarnitine may offer a protective pharmacological effect against cataractogenesis.