Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Heterobifunctional cross-linkers containing 4,9-dioxa-1,12-dodecanediamine spacers

G M Johnson1, J P Albarella, C Petry

  • 1Organic Chemistry Group, Bayer Corporation, Elkhart, Indiana 46515, USA.

Bioconjugate Chemistry
|May 1, 1997
PubMed
Summary

Researchers synthesized novel heterobifunctional linker arms. These linkers were created by modifying a diamine compound using anhydrides or acid chloride for versatile chemical applications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fetally-encoded GDF15 and maternal GDF15 sensitivity are major determinants of nausea and vomiting in human pregnancy.

bioRxiv : the preprint server for biology·2023
Same author

The EndoPredict score provides prognostic information on late distant metastases in ER+/HER2- breast cancer patients.

British journal of cancer·2013
Same author

RNA-based determination of ESR1 and HER2 expression and response to neoadjuvant chemotherapy.

Annals of oncology : official journal of the European Society for Medical Oncology·2012
Same author

EndoPredict improves the prognostic classification derived from common clinical guidelines in ER-positive, HER2-negative early breast cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2012
Same author

[Predictive and prognostic markers of breast cancer. Molecular biological analysis of fixed tumor tissue].

Der Pathologe·2008
Same author

Association analysis of the IGF1 gene with childhood growth, IGF-1 concentrations and type 1 diabetes.

Diabetologia·2008

Area of Science:

  • Organic Chemistry
  • Bioconjugation Chemistry

Background:

  • Heterobifunctional linkers are crucial for bioconjugation and drug delivery.
  • The synthesis of novel linker structures is essential for advancing molecular assembly and targeted therapies.

Purpose of the Study:

  • To prepare a series of novel heterobifunctional linker arms.
  • To functionalize (tert-butoxycarbonyl)-4,9-dioxa-1,12-dodecanediamine for creating diverse chemical structures.

Main Methods:

  • Functionalization of (tert-butoxycarbonyl)-4,9-dioxa-1,12-dodecanediamine.
  • Utilizing anhydrides and acid chlorides as reactive agents.
  • Synthesis of protected diamine derivatives.

Main Results:

  • A series of heterobifunctional linker arms were successfully synthesized.

Related Experiment Videos

  • The functionalization yielded stable and reactive intermediates.
  • The prepared linkers offer potential for diverse conjugation strategies.

    • Conclusions:

    • The developed method provides a versatile route to heterobifunctional linkers.
    • These linkers can be employed in various applications, including drug development and materials science.
    • Further studies can explore the specific applications of these novel linker arms.