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Related Experiment Videos

Azole resistance in Candida

D W Denning1, G G Baily, S V Hood

  • 1Department of Infectious Diseases and Tropical Medicine, North Manchester General Hospital, UK.

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
|April 1, 1997
PubMed
Summary

Antifungal resistance in Candida is a growing concern. Susceptibility testing is feasible and shows a link between fluconazole resistance and treatment failure in mucosal infections, highlighting the need for resistance monitoring.

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Area of Science:

  • Medical Mycology
  • Antimicrobial Resistance
  • Clinical Microbiology

Background:

  • Increasing resistance of Candida species to azole antifungal agents poses a significant clinical challenge.
  • Azole antifungals like fluconazole and ketoconazole are primary treatments for Candida infections.
  • Monitoring antifungal resistance is crucial for effective treatment strategies.

Purpose of the Study:

  • To assess the feasibility and desirability of antifungal susceptibility testing for Candida species.
  • To evaluate the correlation between in vitro Candida resistance and clinical outcomes of azole therapy.
  • To determine the clinical relevance of azole resistance in both mucosal and invasive candidiasis.

Main Methods:

  • Performed antifungal susceptibility testing of Candida isolates against fluconazole and ketoconazole.

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  • Correlated in vitro resistance data with clinical outcomes from fluconazole therapy.
  • Focused on analyzing resistance patterns in mucosal candidiasis and invasive candidiasis.

    • Main Results:

    • Antifungal susceptibility testing for Candida against fluconazole and ketoconazole is demonstrated as feasible and desirable.
    • A strong correlation was observed between in vitro Candida resistance and clinical failure in fluconazole therapy for mucosal candidiasis.
    • The relationship between azole resistance and clinical failure in invasive candidiasis requires further investigation.

    Conclusions:

    • Antifungal susceptibility testing for Candida is a valuable tool, particularly for fluconazole.
    • In vitro resistance to fluconazole correlates with treatment failure in mucosal candidiasis.
    • Further research is needed to clarify the impact of azole resistance on invasive candidiasis outcomes and to monitor resistance trends.