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Inclusion of trithia[5]heterohelicene by various serum albumins. An effective probe for chiral discrimination
K Yamada1, R Ishii, H Nakagawa
1Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan.
Chemical & Pharmaceutical Bulletin
|May 1, 1997
Abstract:
Racemic 2-hydroxymethyltrithia[5]heterohelicene (2-HT), which has a labile helical structure was incorporated into serum albumins of nine species in 1% ethanolic aqueous solution, giving 1:1 complexes which exhibited induced circular dichroism spectra with species specificity. The application of 2-HT to bovine serum as a probe for chiral recognition revealed that the serum itself manifested an apparent chiral discrimination between enantiomers of 2-HT.