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Leptin and thermogenesis in humans
J A Tuominen1, P Ebeling, M L Heiman
1Department of Medicine, Helsinki University Central Hospital, Finland.
Acta Physiologica Scandinavica
|May 1, 1997
Summary
Marathon running increases energy expenditure and lipid oxidation. Hyperinsulinemia elevates serum leptin, which correlates with increased energy expenditure in healthy men, suggesting leptin
Area of Science:
- Endocrinology
- Human Physiology
- Metabolic Research
Background:
- Leptin is a key hormone regulating energy balance.
- Understanding leptin's role in energy expenditure is crucial for metabolic health.
Purpose of the Study:
- To investigate the impact of marathon running and hyperinsulinemia on serum leptin concentrations and thermogenesis.
- To explore the relationship between leptin levels and energy expenditure in healthy men.
Main Methods:
- 12 healthy men underwent a 4-hour euglycemic hyperinsulinemic clamp.
- Measurements were taken on a control day and after a marathon run.
- Serum leptin, free fatty acid (FFA) concentrations, lipid oxidation, and energy expenditure were assessed.
Main Results:
- Marathon running elevated baseline FFA, lipid oxidation, and energy expenditure.
- Hyperinsulinemia increased serum leptin by 35-45% on both control and post-marathon days.
- The increase in energy expenditure during insulin clamp correlated with serum leptin levels.
Conclusions:
- Hyperinsulinemia stimulates leptin secretion in healthy individuals.
- Leptin concentration is positively associated with energy expenditure, suggesting its regulatory role in human metabolism.
- These findings highlight leptin's involvement in the physiological response to exercise and metabolic challenges.