[Clinical experience with r30730/Janssen in anaesthesia for ophthalmic surgery (author's transl)]

Fentanyl was replaced by R 30730/Janssen (Fentatienyl) for neurolept analgesia (with intubation) of 34 persons who had ophthalmic surgery on account of detachment of the retina. The effects of the drug on the size of the pupils, blood pressure, heart rate and respiration were observed; also the duration of analgesia and the incidence of nausea and vomiting. There was a very slight negative effect on the size of the pupil, similar to that seen with halothane; systolic blood pressure fell by an average of 20%; the duration of analgesia and the degree of respiratory depression varied considerably. 12 of the 35 patients suffered from marked nausea and vomiting after the operation.