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Codistribution of the dopamine D3 receptor and glucocorticoid receptor mRNAs during striatal prenatal development in
1Division of Cellular and Molecular Neurochemistry, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.
Abstract:
Glucocorticoids and dopamine (DA) may affect brain development and permanently programme central nervous system (CNS) responses. The ontogeny of the striatal glucocorticoid receptor (GR) mRNA and of DA D1, D2 and D3 receptor subtype mRNAs were, therefore, studied by means of in situ hybridization techniques. The expression of GR and the dopamine D3 receptor mRNAs but not of DA D1 and D2 receptor subtype mRNAs were observed in the striatal neuroepithelium during all prenatal stages studied (E14.5-E20.5). These results suggest that GR may directly influence striatal developmental processes, possibly involving the dopamine D3 receptor.