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Related Experiment Videos

True histiocytic lymphoma: is it an entity?

M T Elghetany1

  • 1Department of Pathology, University of Texas Medical Branch, Galveston 77555-0743, USA.

Leukemia
|May 1, 1997
PubMed
Summary

Distinguishing true histiocytic lymphoma from monocytic leukemia tissue involvement is challenging. Unifying these as extramedullary myeloid tumors of monocytic origin simplifies diagnosis and treatment.

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Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Monocytes and macrophages share close biological origins and functions.
  • True histiocytic lymphoma is classified as a non-Hodgkin's lymphoma.
  • Monocytic leukemia tissue involvement is termed extramedullary myeloid cell tumor or granulocytic sarcoma.

Purpose of the Study:

  • To address the diagnostic challenges in differentiating true histiocytic lymphoma from extramedullary monocytic leukemia.
  • To propose a unified classification and treatment approach for these related hematologic neoplasms.

Main Methods:

  • Review of existing morphologic, cytochemical, immunocytochemical, and molecular diagnostic methods.
  • Analysis of the relationship between monocytes, macrophages, and myeloid leukemias.

Main Results:

  • Current methods are insufficient to reliably distinguish between true histiocytic lymphoma and monocytic leukemia tissue involvement.
  • The two conditions exhibit significant overlap in their cellular origins and characteristics.

Conclusions:

  • True histiocytic lymphoma and extramedullary monocytic leukemia likely represent a spectrum of the same disease process.
  • A unified classification as 'extramedullary myeloid cell tumor of monocytic origin' is proposed.
  • This unified approach would guide treatment with antileukemic chemotherapy.

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