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Elevated serum ferritin level in acute myocardial infarction
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|January 1, 1997
Summary
Serum ferritin levels increase significantly in patients following acute myocardial infarction (AMI). This rise in ferritin, particularly in monocytes, suggests it can be a useful diagnostic marker for AMI.
Area of Science:
- Biochemistry
- Cardiology
- Hematology
Background:
- Acute myocardial infarction (AMI) is a critical cardiovascular event.
- Accurate and timely diagnosis of AMI is essential for patient outcomes.
- Biomarkers for AMI diagnosis are continuously being investigated.
Purpose of the Study:
- To investigate the dynamic changes in serum ferritin levels post-AMI.
- To explore the role of peripheral blood monocytes in elevated ferritin levels after AMI.
- To evaluate the potential of serum ferritin as a diagnostic marker for AMI.
Main Methods:
- Serum ferritin levels were measured in 20 AMI patients over 10 days post-infarction.
- Ferritin content in peripheral blood monocytes was assessed.
- A control group of patients with non-AMI chest pain was included.
- In vitro studies incubated monocytes with hydrocortisone.
Main Results:
- Serum ferritin levels gradually increased from day 2, peaking at four times the initial level by day 6 post-AMI.
- A significant increase in monocyte ferritin content was observed on day 5 post-AMI.
- Control group patients showed normal serum ferritin levels.
- Hydrocortisone incubation enhanced ferritin content in healthy monocytes.
Conclusions:
- Elevated serum ferritin levels are a characteristic finding in the acute phase following AMI.
- Peripheral blood monocytes may contribute to the increased serum ferritin post-AMI, potentially activated by stress-induced factors like steroids.
- Serum ferritin measurement can serve as a complementary diagnostic tool for confirming AMI.