Two patients with recurrent melioidosis after prolonged antibiotic therapy
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M H Silbermann1, I C Gyssens, H P Endtz
1Department of Hematology, University Hospital Rotterdam, The Netherlands.
Abstract:
Melioidosis is a tropical infectious disease caused by Burkholderia (Pseudomonas) pseudomalleï. Clinically manifest melioidosis occurs mostly in people with underlying disorders. Melioidosis is a disease with protein manifestations and a high rate of relapse. Two patients with infection due to Burkholderia pseudomalleï after a visit to Thailand are described. Both patients presented with sepsis and appropriate therapy was initiated and continued for several months. Despite such long-term antimicrobial treatment, both patients had a relapse after cessation of therapy. It is unclear if recurrent melioidosis can be prevented by prolonging the treatment even further.
Insights
Melioidosis, a tropical infectious disease caused by Burkholderia pseudomallei, can relapse even after prolonged antimicrobial therapy. This case study highlights treatment challenges and the uncertainty of preventing recurrent melioidosis.
Area of Science:
- Infectious Diseases
- Tropical Medicine
- Bacteriology
Background:
- Melioidosis is an infectious disease endemic in tropical regions, caused by Burkholderia pseudomallei.
- The disease often affects individuals with pre-existing health conditions and is characterized by diverse clinical presentations and a high relapse rate.
- Travelers to endemic areas, such as Thailand, are at risk of acquiring this infection.