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Synthesis of thiophene carboxamide derivatives as serotonin 5-HT4 receptor agonists
1CIFA Centro de Investigatión en Farmacobiología Aplicada, Universidad de Navarra, España.
Abstract:
New thiophene carboxamide derivatives 3 (a-j) were synthesized as serotonin 5-HT4 receptor agonists. Preliminary results showed that the compounds 3a, 3d, 3e and 3f caused concentration dependent relaxation of carbachol-induced contraction in tunica muscularis mucosae in rat oesophagus.