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[Immunomodulating action of eubiotics]
T K Lopatina1, M S Bliakher, V N Nikolaenko
1NII of Epidemiology and Microbiology of GN Gabrichevskií, Moscow.
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
|January 1, 1997
Summary
Three bacterial agents, bifidumbacterin, acylact, and biosporine, were studied for their immunomodulating effects in patients with intestinal dysbacteriosis. These agents helped normalize immune parameters in various patient groups, with bifidumbacterin and acylact showing potent yet mild immunomodulatory actions.
Area of Science:
- Microbiology
- Immunology
- Gastroenterology
Context:
- Intestinal dysbacteriosis is linked to immune system dysfunction.
- Patients in radionuclide-contaminated areas, with atopic dermatitis, chronic postinfection polyarthritis, or spinal cord injury exhibit altered immunological parameters.
- Lymphocytic populations are often reduced in these patient groups.
Purpose:
- To investigate the immunomodulating potential of three bacterial agents: bifidumbacterin, acylact, and biosporine.
- To assess the efficacy of these agents in normalizing intestinal microflora and immune status.
- To evaluate the safety and specificity of their immunomodulatory effects.
Summary:
- The study examined the effects of bifidumbacterin, acylact, and biosporine on immunological parameters in diverse patient cohorts experiencing intestinal dysbacteriosis.
- Treatment with these bacterial agents led to improved intestinal microflora and normalization of immune functions, particularly lymphocytic populations.
- Bifidumbacterin and acylact demonstrated potent but mild immunomodulatory activity, effectively enhancing suppressed immune systems without significantly impacting normal parameters.
Impact:
- Bacterial agents can serve as effective immunomodulators for conditions associated with intestinal dysbacteriosis.
- Bifidumbacterin and acylact show promise for therapeutic use in restoring immune balance.
- Further research is warranted to fully elucidate the immunomodulatory mechanisms of biosporine across various health and disease states.