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Perhydrogenation of tabersonine, ans Aspidiosperma indole alkaloid
G Lewin1, C Schaeffer, C Dacquet
1Laboratoires de Phamacognosie, Faculté de Pharmacie, Caen, France.
Journal of Natural Products
|April 1, 1997
Abstract:
The natural indole alkaloid (-)-tabersonine (1) easily provided (-)-decahydrotabersonine (4a), isolated as dihydrochloride (4b), by catalytic hydrogenation. Saponification of 4a led to the beta-amino acid 5. A binding study of 1, 4b, and 5 on various receptors and ionic channels showed that none of the compounds had a strong affinity for the receptors tested.