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[Transplantation today]

F Mühlbacher1

  • 1Allgemeines Krankenhaus der Stadt Wien.

Der Radiologe
|March 1, 1997
PubMed
Summary
This summary is machine-generated.

This review covers key issues in organ transplantation, focusing on ethical considerations and organ availability. It highlights current transplantation frequencies and survival rates for end-stage organ disease patients.

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Area of Science:

  • Transplantation Medicine
  • Organ Availability
  • Graft Survival Rates

Context:

  • Current state of perfused organ transplantation.
  • Ethical and legal considerations in living donor transplantation, brain death, donor consent, and organ allocation.
  • Impact of donor and organ availability on transplantation frequencies for end-stage organ disease.

Purpose:

  • Highlight key issues in transplantation medicine today.
  • Summarize basic information on the current state of perfused organ transplantation.
  • Emphasize ethical and legal considerations in organ donation and allocation.

Summary:

  • Organ donor rates of 25-30 per million inhabitants may suffice for kidney replacement therapy, while 15-20 liver transplantations per million could meet needs for non-malignant end-stage liver disease.

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  • Techniques like split liver transplantation can increase organ utilization.
  • One-year graft survival for kidney transplants is 85-90%; patient survival for heart and liver transplants exceeds 80%.

    • Impact:

    • Whole organ transplantation for kidneys, hearts, and livers are routine; lung transplantation is nearing standard status.
    • Long-term graft survival depends on chronic rejection, patient comorbidity, and original disease.
    • While technically established, the indications for pancreas and combined pancreas-kidney transplantation remain controversial.